Additional Piece:
As we age, our nutritional requirements change, affecting our metabolic health and longevity. According to recent studies, different nutritional interventions involving varied intake of calories and protein can improve the health and life expectancy of rodents and primates. Researchers are now investigating how these findings can be applied to humans to improve metabolic health, increase disease-free life span, and life expectancy.
In a study published in Geroscience on April 28, 2023, researchers in Japan found that moderate-protein diets were the most effective at improving metabolic health in mice approaching old age. The team recruited young and middle-aged male C57BL/6NCr mice and fed them isocaloric diets with variable protein content (5 to 45%) for two months. The different protein diets’ effects were evaluated based on measurements of skeletal muscle weight, liver and plasma lipid profiles, and self-organizing map (SOM) cluster analysis of amino acid profiles. The researchers observed that consumption of a low-protein diet led to the development of mild fatty liver, while a moderate protein diet lowered blood glucose concentrations and lipid levels in both liver and plasma. These findings indicate that a balanced diet with moderate amounts of protein could be the key to a long and healthy life.
The optimal balance of macronutrients for ideal health outcomes varies throughout different life stages. Protein requirements change throughout life, being highest in the youngest reproductive mice, declining at midlife, and increasing again in older mice. As protein efficiency decreases, the same pattern is likely observed in humans. Therefore, increasing daily protein intake at meals could promote people’s metabolic health. Furthermore, the ideal balance of macronutrients in the diet at each life stage could also extend the span of health.
In addition to protein intake, there are other factors to consider when trying to improve metabolic health and slow aging. Here are some practical tips based on recent studies and expert advice:
1. Cut back on sugar and processed foods: A high-sugar and processed food diet can lead to insulin resistance, a primary cause of metabolic disease.
2. Exercise regularly: Exercise can help prevent age-related muscle loss and improve insulin sensitivity, reducing the risk of metabolic disease.
3. Get enough sleep: Sleep deprivation can lead to insulin resistance, increasing the risk of metabolic disease.
4. Eat a variety of whole foods: A balanced diet with a variety of whole foods can help provide essential nutrients for optimal metabolic health.
5. Consider intermittent fasting: Intermittent fasting has been shown to improve metabolic health and increase lifespan in rodents.
In conclusion, understanding the link between dietary macronutrients and metabolic health is crucial to improving our health and longevity. By adopting a balanced diet with moderate amounts of protein and practicing healthy lifestyle habits, we can slow the aging process and live a long and healthy life.
Summary:
Researchers in Japan fed young and middle-aged mice isocaloric diets with varying amounts of protein to study the appropriate amounts of dietary macronutrients that can improve metabolic health. They found that mice were metabolically healthier when fed moderate-protein diets, which could provide valuable information on the development of nutritional interventions and the improvement of metabolic health in people. Additionally, a balanced diet with moderate amounts of protein could be the key to a long and healthy life. As we age, our nutritional requirements change, making it essential to adopt healthy lifestyle habits, such as cutting back on sugar and processed foods, exercising regularly, getting enough sleep, and eating a variety of whole foods. By doing so, we can slow the aging process, reduce the risk of metabolic disease, and live a long and healthy life.
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Eating nutritious foods can improve metabolic health and slow aging. But what are the appropriate amounts of dietary macronutrients that can help achieve this? To answer this, researchers in Japan fed isocaloric diets with varying amounts of protein to young and middle-aged male mice. They found that the mice were metabolically healthier when fed moderate-protein diets. These findings could provide valuable information on the development of nutritional interventions and the improvement of metabolic health in people.
As the proverb says “You are what you eat”, the type of food we eat influences our health and longevity throughout our lives. In fact, there is a direct association between age-related nutritional requirements and metabolic health. Optimal age-appropriate nutrition can help maintain metabolic health, thereby improving an individual’s healthy span (disease-free life span) and life expectancy. Different nutritional interventions involving a varied intake of calories and protein are known to improve the health and life expectancy of rodents and primates. Furthermore, recent studies have also reported the association of dietary macronutrients (protein, carbohydrate, fat) with cardiometabolic health and aging in mice. However, the amount of protein that should be consumed to maintain metabolic health is unknown.
In a new study published in geroscience On April 28, 2023, a team of researchers led by Assistant Professor Yoshitaka Kondo of Waseda University, Japan, investigated the amount of dietary protein needed to improve metabolic health in mice approaching old age. The team, which also included Dr. Takuya Chiba, Faculty of Human Sciences, Waseda University, Dr. Akihito Ishigami, Molecular Regulation of Aging, Tokyo Metropolitan Institute of Geriatrics and Gerontology, Dr. Hitoshi Aoki, Research and Development Division , Nichirei Foods Inc. and Dr. Shin-Ichiro Takahashi, Department of Animal Sciences and Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo. They recruited young (6 months) and middle-aged (16 months) male C57BL/6NCr mice that were fed isocaloric diets of variable protein content (5 to 45%) for two months. After two months, the effect of the different protein diets was evaluated based on measurements of skeletal muscle weight, liver and plasma lipid profiles, and self-organizing map (SOM) cluster analysis of amino acid profiles. plasmatics.
When asked about the motivation behind his study, Kondo explains: “The optimal balance of macronutrients for ideal health outcomes can vary throughout different life stages. Previous studies show the possibility of minimizing mortality age-specific throughout life by changing the ratio of dietary protein to carbohydrates as we approach old age in mice.However, the amount of protein that should be consumed to maintain metabolic health as we approach old age is not yet it’s clear.”
The team observed that consumption of a low-protein diet led to the development of mild fatty liver, with higher levels of liver lipids in middle-aged mice compared to young mice. In contrast, a moderate protein diet lowered blood glucose concentrations and lipid levels in both liver and plasma. These findings indicate that a moderate protein diet (25% and 35%) kept young and middle-aged mice metabolically healthier.
By examining the effect of different protein diets on plasma amino acid concentrations in mice of both age groups, the researchers found that the plasma concentration of individual amino acids varied with age and dietary protein content. This was further validated by SOM analysis of plasma amino acids. In addition, plasma amino acid profiles revealed by SOM analysis showed the correlation between intake of different proteins and variable amounts of liver triglyceride and cholesterol levels.
Discussing the impact of his study on public health, Kondo comments: “Protein requirements change throughout life, being highest in the youngest reproductive mice, declining at midlife, and increasing again in older mice.” as protein efficiency decreases. The same pattern is likely to be observed in humans. Thus, it could be assumed that increasing daily protein intake at meals could promote people’s metabolic health. Furthermore, the ideal balance of macronutrients in the diet at each life stage could also extend the span of health.”
In conclusion, a balanced diet with moderate amounts of protein could be the key to a long and healthy life.
https://www.sciencedaily.com/releases/2023/05/230531101947.htm
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