Researchers from the Department of Surgery at Michael E. Debaky at Baylor College of Medicine, the Qimr Berghofer Medical Research Institute in Brisbane, Australia, and collaborating institutions report an innovative discovery in cardiac regeneration that offers a new hope for the treatment of ischemic heart failure. Posted in NPJ regenerative medicineThe study reveals a novel approach to promote the proliferation of cardiomiocytes.
“When the heart cannot replace the injured cardiomiocytes with other health Cardiotracic in Baylor.
Previous studies showed that calcium plays an important role in the proliferation of cardiomyocytes. In the current study, Abouleisa and his colleagues explored how the entry of calcium modulator into the cardiomyocytes would affect their proliferation.
“We found that preventing calcium entry into cardiomiocytes improves the expression of genes involved in cell proliferation,” said Abouleisa. “We foresee calcium entry by inhibiting the type L calcium channel (LTCC), a protein that regulates calcium in these cells. Our findings suggest that LTCC could be an objective to develop new therapies to induce the proliferation and regeneration of cardiomiocytes.”
The study demonstrates that the pharmacological and genetic inhibition of LTCC can induce the replication of cardiomyocytes and that this occurs by modulating the activity of calcineurin, a known regulator of the proliferation of cardiomiocytes. This innovative approach showed promising results in both human cardiac slices grown in the laboratory and in living animals.
“The multiple collaborations of Abouleisa led to a discovery that can revolutionize the use of current medications that regulate calcium entry into cells, such as nifedipine, in patients with heart failure,” said Dr. Tamer Mohamed, co -author and director of the cardiac regeneration of the Baylor College of Medicine.
The co -author, Dr. Todd K. Rosengart, president and professor of the Department of Surgery of Michael E. Debakey, emphasized that, “the premise of regenerating the cardiac fabric, which once seemed an impossible dream, is approaching almost daily. The work of Dr. Abouleis in the future non-dtesto-dtesto “”.
Abouleisa and his colleagues research highlights the importance of addressing calcium signaling roads to unlock the regenerative potential of the heart and opens new paths to develop cardiac regenerative therapies, which can transform the treatment scenario for patients suffering from heart failure.
Other taxpayers to this work include Lynn Ac Devilee, Abou Bakr M Salama, Jessica M Miller, Janice D Reid, Qinghui Ou, Nourhan M Baraka, Kamal Abou Farraj, Madiha Jamal, Yibing Nong, Douglas Andres, Jonathan Satin and James and Hudson.