Wound-Healing Ink Developed to Speed Up Natural Healing Process
Researchers at the ACS Applied Materials and Interfaces have developed a wound-healing ink that can actively encourage the body to heal faster than it normally would. The ink can be spread on a cut of any shape using a 3D printing pen, and in mice, the technology almost completely healed wounds in just 12 days.
Background
When skin is cut or torn, the body’s natural “building kit” kicks in to repair it, regenerating broken blood vessels and eventually forming a scar. Many techniques used to heal wounds can’t do much more than help the body do its job better. Bandages or stitches are used to prevent further bleeding, while antibiotics work to prevent complications from infections.
The innovation
By adding build crew members to a wound-healing treatment or bandage, researchers believe they can speed up the natural healing process. Specifically, white blood cells or the extracellular vesicles (EVs) secreted by them play an important role in promoting blood vessel formation and reducing inflammation during healing. By incorporating these electric vehicles into a hydrogel-based wound healing ink that could be painted on cuts of any shape, researchers have developed a system called PAINT, or “portable bioactive ink for tissue healing”.
The Process
The team used EVs secreted by macrophages combined with sodium alginate. These components were combined in a 3D printing pen, where they were mixed at the pen tip and formed a strong gel at the injury site within three minutes. The EVs promoted blood vessel formation and reduced inflammatory markers in human epithelial cells, switching them into the “proliferative” or growth phase of healing. PAINT was also tested in injured mice, where it promoted the formation of collagen fibers.
The Findings
The PAINT-treated mice had almost completely healed from a large wound after 12 days, compared with the untreated mice, which were not as far along in the healing process at that point. The researchers say this work could help heal a wide variety of cuts quickly and easily, without the need for complex procedures.
Additional Thoughts
The development of wound-healing ink, PAINT, which incorporates electric vehicles, is a promising innovation for the medical industry. The ease of use of the system means that it can be used without the need for complex procedures, and it can provide a natural healing solution to cuts of any shape, which can be a great alternative to traditional wound healing techniques.
This revolutionary invention may have the potential to change the way we think about how we treat wounds and offer an alternative to the current conventional techniques of healing. It not only reduces the time it takes to heal but also offers a scientific solution that enhances the natural healing process, which is always a huge plus in any medical treatment.
The result from the tested mice shows that this system can significantly reduce the time it takes to heal wounds, which is an excellent sign. The researchers’ findings have the potential to break barriers and improve the wound-healing industry.
This study sparks a lot of interest for ongoing researchers who focus on discovering unique ways to enhance the healing process. It is worth taking a moment to appreciate innovative researchers who dedicate themselves to developing the medical industry and are continuously researching ways to aid in the advancement of health and well-being.
Summary
The body has natural regenerative abilities, but sometimes, it may require additional aid to speed up the healing process. Researchers at the ACS Applied Materials and Interfaces have developed wound-healing ink, PAINT, which incorporates electric vehicles that promote the formation of blood vessels and reduce inflammation, encouraging cells to grow faster and form a strong scar. This ink is used in conjunction with a 3D printing pen, and testing on injured mice shows that the system can significantly reduce wound healing time. This innovation offers a natural, easy-to-use alternative to traditional wound-healing techniques, bringing healing to cuts of various shapes without the need for complex procedures.
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The body is pretty good at healing itself, although more serious injuries may require bandaging or stitching. But researchers who publish in ACS Applied Materials and Interfaces have developed a wound-healing ink that can actively encourage the body to heal by exposing the cut to vesicles from the immune system. The ink can be spread on a cut of any shape using a 3D printing pen, and in mice, the technology almost completely healed wounds in just 12 days.
When skin is cut or torn, the body’s natural “building kit” kicks in to repair it, eliminating any bacterial invaders, regenerating broken blood vessels, and eventually forming a scar. Many techniques used to heal wounds can’t do much more than help the body do its job better. Bandages or stitches are used to prevent further bleeding, while antibiotics work to prevent complications from infections. But by adding build crew members to a wound-healing treatment or bandage, you could actually speed up the natural healing process. Specifically, white blood cells or the extracellular vesicles (EVs) secreted by them play an important role in promoting blood vessel formation and reducing inflammation during healing. So Dan Li, Xianguang Ding and Lianhui Wang wanted to incorporate these electric vehicles into a hydrogel-based wound healing ink that could be painted on cuts of any shape.
The team developed a system called PAINT, or “portable bioactive ink for tissue healing,” using electrical vehicles secreted by macrophages combined with sodium alginate. These components were combined in a 3D printing pen, where they were mixed at the tip of the pen and formed a strong gel at the injury site within three minutes. The EVs promoted blood vessel formation and reduced inflammatory markers in human epithelial cells, switching them into the “proliferative” or growth phase of healing. PAINT was also tested in injured mice, where it promoted the formation of collagen fibers. The PAINT-treated mice had almost completely healed from a large wound after 12 days, compared with the untreated mice, which were not as far along in the healing process at that point. The researchers say this work could help heal a wide variety of cuts quickly and easily, without the need for complex procedures.
https://www.sciencedaily.com/releases/2023/06/230601160006.htm
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