Dultos under 50 were more than twice the risk of having a brain brain spill or other non -traditional stroke risk factors instead of traditional risks, such as high blood pressure, according to research published today in StrokeThe scientific magazine reviewed by Pares of the American Stroke Association, a division of the American Heart Association.
Previous investigations indicate that the ischemic stroke rate (caused by clots) between adults aged 18 to 49 is increasing and driven by a corresponding increase in cryptogenic strokes (strokes strokes of unknown cause) in adults without traditional risk factors, including high blood pressure, smoking, obesity, obesity, obesity and type 2 diabetes.
“Up to half of all ischemic strokes in young Stroke at the Neurocenter, Helsinki Helsinki Hospital in Helsinki in Helsinki in Helsinki in Helsinki in Helsinki, Helsinki Hospital in Helsinki, Finland. “We must also carefully detect people after they have a stroke to avoid future blows.”
The researchers analyzed data for more than 1,000 adults between 18 and 49 years in Europe, with an average age of 41 years. Half of the participants had experienced a cryptogenic ischemic stroke, while half had no history of stroke. The study examined associations of 12 traditional risk factors, 10 non -traditional risk factors and five specific risk factors for women (such as gestational diabetes or pregnancy complications). The researchers also closely reviewed the participants with a heart defect called Patent Form Ovale (PFO), a hole between the upper hearts of the heart. A PFO is usually harmless, but it is known that it increases the probabilities of stroke. The study aimed at what risk factors contribute more to inexplicable stroke.
The analysis found:
- Traditional risk factors were more strongly associated with stroke in men and women without PFO.
- In contrast, non -traditional risk factors, such as blood clots in the veins, migraine with aura, chronic kidney disease, chronic liver disease or cancer, were more strongly associated with stroke among study participants with a PFO.
- In those without PFO, each additional traditional risk factor increased the risk of stroke by 41%, while each non -traditional risk factor increased the risk of stroke by 70%.
- Risk factors related to women also increased the risk of stroke by 70% independent of traditional and non -traditional risk factors.
- Among the participants with a PFO, each traditional risk factor increased the risk of stroke by 18%. However, after considering individual demographic factors, such as age, sex and level of education, non -traditional risk factors that double the chances of having an ischemic stroke.
The researchers also analyzed the attributable risk of the study population (determining how a disease would be affected if a certain risk factor was eliminated). To calculate the risk of the attributable population, the researchers analyzed each risk factor and their contribution to the highest risk separately and found:
- For stroke that occur without a PFO, traditional risk factors represented approximately 65% of cases, non -traditional risk factors contributed 27% and specific risk factors of women constituted almost 19% of cases.
- On the contrary, for stroke associated with a PFO, traditional risk factors contributed around 34%, non -traditional risk factors represented 49%and specific risk factors of women represented around 22%.
- In particular, migraine with Aura was the main non -traditional risk factor associated with strokes of unknown origin, with a risk attributable to the population of approximately 46% for strokes between people with a PFO and approximately 23% for those without PFO, which indicates a higher risk for people with PFO.
“We were surprised by the role of non -traditional risk factors, especially headaches per migraine, which seems to be one of the main risk factors in the development of strokes in younger adults,” said Putaala. “Our results should inform the professional health community to develop a more personalized approach to the evaluation and management of risk factors. We should ask young women if they have a history of headaches by migraine and other non -traditional risk factors.”
The president of the American Association of the Heart of Clinical Cardiology (CLCD)/Committee of Health Sciences of Stroke, Tracy E. Madsen, MD, Ph.D., FAH Younger can have a higher risk than young men than young men. Madsen, who did not participate in the study, is also an associate professor, Vice President of Research in Emergency Medicine and director of the epicenter at the Faculty of Medicine of Robert Larner, MD of the University of Vermont in Burlington, Vermont.
Study limitations include being an observation study, which means that it was a review and analysis of existing health data on patients enrolled in another test or database; Therefore, the findings of this study cannot prove the cause and effect. The study was also based on risk factors informed by the patient, which can affect precision. In addition, 95% of the participants were self -informed to be white adults of European descent, which limits the applicability of the findings to other populations.
Study details, background and design:
- The study included 523 adults from 18 to 49 years (median of 41 years; 47.3% women; 37.5% with PFO) who had suffered a cryptogenic ischemic stroke and 523 pairs of similar age without a history of stroke.
- The purpose of the review was to evaluate traditional and non -traditional risk factors associated with a higher risk of cryptogenic ischemic stroke.
- The participants enrolled in the search for explanations for the cryptogenic stroke in young November 2013 and January 2022.