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Research shows how hormone can reverse fatty liver disease in mice

A pioneer research study published today in Cell metabolism It details how the FGF21 hormone (fibroblast growth factor 21) can reverse the effects of fatty liver disease on mice. The hormone works mainly by pointing to the brain that improves liver function.

The researcher at the University of Oklahoma, Matthew Pothoff, Ph.D., is the main author of the study, which provides valuable information about the mechanism of action of the hormone, which is a goal for a new class of highly anticipated medications found in clinical trials of phase 3.

“Fatty liver disease, or MASLD (steathotic liver disease associated with metabolic dysfunction), is an accumulation of fat in the liver. It can progress to purify (the steatohepatitis associated with metabolic dysfunction) during which fibrosis and, final The people of the people, and it is about the fact that they are only pyrosis, and it is a very large treatment in the United States, which affects 40% of people’s people, and it is about the fact that it is only about Cirro, and it is a very large treatment in 40% of the people of the people of the people, and it is about that it is a circus, and it is a very large treatment in the United States, which affects 40% of people. of the people.

The study results showed that FGF21 was effective to cause signaling in the model species that changed the liver metabolism. In doing so, the liver fat was reduced and fibrosis was invested. The hormone also sent a separate signal directly to the liver, specifically to lower cholesterol.

“It is a feedback circuit where the hormone sends a signal to the brain and the brain changes nerve activity to the liver to protect it,” Pottoff said. “Most of the effect comes from the signal to the brain instead of pointing the liver directly, but together, the two signs are powerful in their ability to regulate the different types of lipids in the liver.”

Similar to the family of medications to lose weight known as LPG-1 (peptide similar to a glucagon 1), which help regulate blood sugar and appetite levels, FGF21 acts on the brain to regulate metabolism. In addition, both are hormones produced from peripheral tissues, LPG-1 of the intestine and FGF21 of the liver, and both work by sending a signal to the brain.

“It is interesting that this hormone/metabolic drug works mainly when pointing to the brain instead of the liver directly, in this case,” he said. “FGF21 is quite powerful because it not only led to a fat reduction, but also measured the reversal of fibrosis, which is the pathological part of the disease, and did it while mice still ate a diet that would cause the disease. Now, we not only understand how the hormone works, but guides us in the creation of even more specific therapies in the future.”

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