It is remarkable when a scientific study reaches the brand of the decade, but when the issue is the healthy aging of people who have lived 10 times longer, it only means that there is still much more to learn.
This month, the researchers who participate in the Cilento initiative on the aging results or the CIAO study will meet at Acciaroli (POLICAL-CILETO) Salerno, Italy, to review a decade of work and plan their next steps. Released in 2016, the CIAO study seeks to identify key factors (biological, psychological and social) that promote healthy aging and extreme longevity.
The Natural Park of the Cilento region in southern Italy is home to approximately 300 residents who are over 100 years old and have a robust health. The widest region is remarkable during the long life of its residents. It was the original research source for Ancel Keys, the US physiologist who studied the influence of the diet in health and first promoted the benefits of the Mediterranean diet.
Scientists hope to reveal the longevity secrets of the Cilento region using a variety of tools to measure metabolomics, biomes, cognitive dysfunction and protein biomarkers for the risk of heart disease, Alzheimer’s, renal disease and cancer, along with psychological, social and lifestyle surveys.
“There is not a single secret to living a long and healthy life,” said Salvatore Di Somma, MD, main Italian researcher of the study, founder of Great Health Science and Symposium Cop-Starair. “There are many secrets, most of which we are just beginning to understand and, more importantly, learn how they could apply to everyone’s well -being. The notable centenarians in our study are leading the way.”
The study by CIAO is a multi -sennsion collaboration that includes Sanford Burnham Prebys, a non -profit biomedical research institute in San Diego, the Sanford stem cell institute at the University of California in San Diego, Universidad La Sapienza in Rome and great health sciences, a network of public and private research organizations based on Rome, Italy.
The Symposium from May 22 to 23, officially called the “study of CIAO: a decade of science on healthy aging, stem cells and revealed secrets of longevity”, will feature a series of scientists and doctors who describe their work and findings, from general demographic and epidemiological aspects to the deepest immersions in the age of brain cell of staticled cells and RNAs.
“Understanding how we age and how we could get older is a timeless search,” said David Brenner, MD, president and CEO of Sanford Burnham Prebys and co -president of the symposium. “Ten years later, with the benefit of new and emerging technologies and global collaborations, we have traveled a long way. It is important to see where we are now and what will be our questions and key steps in the next 10 years.”
A current CIAO project takes advantage of genetic, epigenetic, transcriptomic, metabolic, proteomic and environmental analysis to identify key taxpayers to extreme longevity. Supported by the Sanford Stem Cell Institute in UC San Diego, researchers use induced pluripotent stem cells (IPSC) derived from centenarians to model metabolic and metabolic tensions in humans.
“This study will provide new ideas about the development of regenerative medicine strategies to promote healthy aging and the treatment of age -related conditions,” said Tatiana Kisseleva, MD, PHD, Surgery Professor at the Faculty of Medicine of the UC San Diego and director of the Center for Medicine and Space Medicine of Celadas Montín de Sanford. Preliminary findings are expected to be presented in the symposium.
The study of CIAO has already generated multiple published articles and intriguing findings. Among them:
- In a 2016 presentation, the researchers reported that the oldest residents who participated in the CIAO study exhibited a solid microcirculation of comparable blood in efficiency to the younger 30 years older. They also noticed that low blood levels of the adrenomedulin peptide were an indicator of a good microcirculation.
- In 2018, using a combination of scales to measure mental and physical well -being, resilience, optimism, anxiety, depression and perceived stress, researchers evaluated 29 non -agenaries and 51 family members between the ages of 51 and 75 years. They found that the study participants of 90 years or more had a bigger physical health but better mental well -being than their young counterparters. Exceptional longevity was characterized by a balance between acceptance and sand to overcome adversities, along with a positive attitude and close links with family, religion and earth, providing a purpose in life.
- In 2020, a transverse sampling of non-agenaries and centenarians, together with the youngest co-urbitants of Cilento, evaluated the key lifestyle, medical, echocardiographic and electrocardiographic characteristics to identify the cardiovascular profile and lifestyle factors associated with longevity. Unlike its youngest co-eating, the Major Group did not smoke, it had lower fasting glucose levels and lower LDL cholesterol despite having half the chances of taking statins. They were physically active and enjoyed relatively low levels of cardiovascular disease, even people with structural cardiac abnormalities experienced less symptoms.
- Also in 2020, the researchers sought to define the neurocognitive profiles of 29 residents of the Cilento region at least 90 years and 49 youngest residents aged 50 to 75 years. They discovered that the oldest cohort seemed to enjoy the cognitive state comparable to its youngest cohabitants without significant differences in oxidative stress markers or the APOE genotype, a genetic variation that determines the risk of a person to develop certain diseases, particularly that of Alzheimer’s. The authors concluded that the results could be related to the optimal adhesion of the major group to the Mediterranean diet, although other positive lifestyle factors and personality traits could be contributing to their healthy aging.
- The researchers who investigate the relationship between loneliness and wisdom compared different age cohorts in San Diego and Cilento, using two validated solitude scales. They did not find significant differences in the levels of loneliness between the groups, but a strong inverse correlation between loneliness and wisdom in all groups. Soledad worsened general health, sleep quality and feelings of happiness, while wisdom improved these measures.